Ferreira, E.G.; Wilke, D.V.; Jimenez, P.C.; Portela, T.A.; Silveira, E.R.; Hajdu, E.; Pessoa, C.; de Moraes, M.O.; Costa-Lotufo, L.V. (2007). Cytotoxic activity of hydroethanolic extracts of sponges (Porifera) collected at Pedra da Risca do Meio Marine State Park, Ceará State, Brazil. pp. 313–318. In: Custódio, M.R., Lôbo- Hajdu, G., Hajdu, E. & Muricy, G. (Eds.), Porifera Research: Biodiversity, Innovation and Sustainability. Série Livros, 28, Museu Nacional, Rio de Janeiro,.

220494

Ferreira, E.G.; Wilke, D.V.; Jimenez, P.C.; Portela, T.A.; Silveira, E.R.; Hajdu, E.; Pessoa, C.; de Moraes, M.O.; Costa-Lotufo, L.V.

2007

Publication

Proceedings of the 7th International Sponge Conference, Buzios 2006

Available for editors   [request]

Marine sponges are well-known as a rich source of bioactive substances. This study aimed on screening the hydroethanolic extracts of 22 sponge species colleted at the Pedra da Risca do Meio Marine State Park, Ceará, off the Northeast coast of Brazil, for antiproliferative, antimitotic and hemolytic activity. After collection, the species were immediately immersed in ethanol and stored at low temperatures (-20°C) until use. The hydroethanolic extracts (HEEs) were obtained by evaporation of the immersion solvent and its residue was reconstituted at a concentration of 20 mg/mL in sterile dimethylsulphoxide (DMSO) to be used in the bioassays. Geodia corticostylifera and Monanchora arbuscula were highly active on all performed assays, followed by Amphimedon compressa, which showed a strong inhibitory activity on cultured cell growth and sea-urchin eggs division, but exhibited only a moderate hemolytic activity.

Brazil

Biochemistry

Porifera

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