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The transcription factor bZIP14 regulates the TCA cycle in the diatom Phaeodactylum tricornutum
Matthijs, M.; Fabris, M.; Obata, T.; Foubert, I.; Franco-Zorrilla, M.; Solano, R.; Fernie, R.; Vyverman, W.; Goossens, A. (2017). The transcription factor bZIP14 regulates the TCA cycle in the diatom Phaeodactylum tricornutum. EMBO J. 36(11): 1559-1576. https://dx.doi.org/10.15252/embj.201696392
In: The EMBO Journal. Nature Publishing Group: Eynsham (P.O. Box 1, Eynsham, Oxford OX8 1JJ). ISSN 0261-4189; e-ISSN 1460-2075
Peer reviewed article  
Available in  Authors 
Keyword
    Phaeodactylum tricornutum Bohlin, 1897 [WoRMS]
Author keywords
    bZIP; diurnal; nitrogen; Phaeodactylum tricornutum; tricarboxylic acidcycle
Authors  Top 
  • Matthijs, M.
  • Fabris, M.
  • Obata, T.
  • Foubert, I.
  • Franco-Zorrilla, M.
  • Solano, R.
  • Fernie, R.
  • Vyverman, W.
  • Goossens, A.
Abstract
    Diatoms are amongst the most important marine microalgae in terms of biomass, but little is known concerning the molecular mechanisms that regulate their versatile metabolism. Here, the pennate diatom Phaeodactylum tricornutum was studied at the metabolite and transcriptome level during nitrogen starvation and following imposition of three other stresses that impede growth. The coordinated upregulation of the tricarboxylic acid (TCA) cycle during the nitrogen stress response was the most striking observation. Through co-expression analysis and DNA binding assays, the transcription factor bZIP14 was identified as a regulator of the TCA cycle, also beyond the nitrogen starvation response, namely in diurnal regulation. Accordingly, metabolic and transcriptional shifts were observed upon overexpression of bZIP14 in transformed P. tricornutum cells. Our data indicate that the TCA cycle is a tightly regulated and important hub for carbon reallocation in the diatom cell during nutrient starvation and that bZIP14 is a conserved regulator of this cycle.
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