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Neuropeptide-amidating activity in the radial nerve cord of Asterias rubens
Bailly, P.; Becker, P.; Flammang, P. (2010). Neuropeptide-amidating activity in the radial nerve cord of Asterias rubens, in: Harris, L.G. et al. Echinoderms: Durham - Proceedings of the 12th international echinoderm conference, Durham, New Hampshire, USA, 7-11 August, 2006. pp. 347-348. http://dx.doi.org/10.1201/9780203869543-c53
In: Harris, L.G. et al. (2010). Echinoderms: Durham - Proceedings of the 12th international echinoderm conference, Durham, New Hampshire, USA, 7-11 August, 2006. CRC Press: [s.l.]. ISBN 978-0-415-40819-6. I–XXXVI pp. http://dx.doi.org/10.1201/9780203869543-f
Available in  Authors 
Document type: Conference paper
Keyword
    Marine/Coastal
Authors  Top 
  • Bailly, P.
  • Becker, P.
  • Flammang, P.
Abstract
    Many metazoan neuropeptides are amidated at their C-terminal end and this amidation appears to be critical for the biological activity of the neuropeptide. The only enzyme known to catalyze this important posttranslational modification is peptidylglycine a-amidating monooxygenase (PAM). PAM is a bifunctional enzyme made of two subunits: the peptidylglycine a-hydroxylating monooxygenase (PHM), requiring copper for its action, and the peptidyl-a-hydroxyglycine a-amidating lyase (PAL). In this study, we investigated the presence PAM-like enzymatic activity in an echinoderm. Extracts from radial nerve cords of the sea star Asterias rubens were incubated in vitro with fluorescent peptide substrata in the presence or absence of Cu++. The results demonstrate a Cu++-dependent amidation activity similar to the PAM action in other metazoans.
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