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Detection of cytochrome P450 1A1 in North Sea dab liver and kidney
Goksøyr, A.; Larsen, H.E.; Blom, S.; Förlin, L. (1992). Detection of cytochrome P450 1A1 in North Sea dab liver and kidney. Mar. Ecol. Prog. Ser. 91(1-3): 83-88
In: Marine Ecology Progress Series. Inter-Research: Oldendorf/Luhe. ISSN 0171-8630; e-ISSN 1616-1599
Also appears in:
Stebbing, A.R.D.; Dethlefsen, V.; Carr, M. (Ed.) (1992). Biological effects of contaminants in the North Sea: Results of the ICES/IOC Bremerhaven Workshop. Marine Ecology Progress Series, 91(1-3). Inter-Research: Amelinghausen. 361 pp., more
Peer reviewed article  
Available in  Authors 
Keywords
    Anatomical structures > Body organs > Animal organs > Excretory organs > Kidneys
    Enzymes > Coenzymes > Cytochromes
    Indicators > Pollution indicators
    Secretory organs > Glands > Exocrine glands > Digestive system > Digestive glands > Liver
    Limanda limanda (Linnaeus, 1758) [WoRMS]
    ANE, North Sea [Marine Regions]
    Marine/Coastal
Authors  Top 
  • Goksøyr, A.
  • Larsen, H.E.
  • Blom, S.
  • Förlin, L.
Abstract
    Liver and kidney tissue of dab Limanda limanda were analyzed during the Bremerhaven Workshop by immunochemical and catalytic assays for cytochrome P450 1A1 induction. Antibodies to cod P450 1A1 cross-reacted with a protein of Mr = 58 000 daltons in the dab liver samples, suggested to be the dab P450 1A1 protein. By employing a recently developed indirect ELISA with these antibodies, we observed elevated levels of P450 1A1 protein in the innermost stations of the German Bight transect in both liver and kidney (head and trunk kidney) samples. Ethoxyresorufin O-deethylase (EROD) activities in trunk kidney were also elevated in the innermost stations. Along the drilling station gradient no induction could be detected. Immuno-detection of the cytochrome P450 1A1 induction response should provide a convenient indicator for biological effects of several classes of organic contaminants.
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